A digestive enzyme that breaks down complex carbohydrates and starches into simple sugars for optimal energy release.
What it is
Amylase (specifically alpha-amylase) is a glycoside hydrolase enzyme that catalyzes the hydrolysis of internal alpha-1,4-glucosidic linkages in starch, glycogen, and related polysaccharides. In dietary supplements, digestive amylase is commonly derived from fungal fermentation (such as Aspergillus oryzae) or non-animal microbial sources. It remains stable across a broader digestive pH range than native salivary or pancreatic amylases, initiating starch breakdown in the stomach.
Also known as: Alpha-Amylase, Digestive Amylase
What it does
- Hydrolyzes dietary starches and complex carbohydrates into maltose, maltotriose, and dextrins.
- Eases digestive workload after carbohydrate-rich meals, helping reduce postprandial fullness and bloating.
- Enhances overall carbohydrate bioaccessibility and nutrient uptake in the upper gastrointestinal tract.
Amplified by probiotics
Exogenous amylase works synergistically with intestinal probiotic bacteria by breaking down complex dietary starches into lower molecular weight oligosaccharides and simple sugars in the stomach and duodenum. As these pre-digested carbohydrate fragments transit into the lower small intestine and colon, live probiotics utilize them as metabolic substrates for fermentation. Furthermore, by reducing carbohydrate malabsorption and preventing undigested starch from rapidly fermenting in an uncontrolled manner, amylase maintains an optimal luminal environment. Live probiotic strains maintain mucosal brush border enzyme expression and mucosal barrier integrity, ensuring efficient uptake of liberated energy sources.
Typical dose
1,000–10,000 DU/day
The evidence
Evidence: strongSupplemental fungal amylase is clinically documented to restore digestive enzyme activity and alleviate symptoms of exocrine insufficiency and functional dyspepsia. Clinical evaluations show enzyme supplementation improves carbohydrate digestion and reduces postprandial abdominal distension (Roxas 2008, Altern Med Rev; Ianiro et al. 2016, Curr Drug Metab).
Safety & who should check first
Highly tolerable with an excellent safety profile; rare hypersensitivity reactions may occur in sensitive individuals. Safe for general supplemental use; consult a physician if managing severe pancreatic disorders.